Sun, Nov 29, 2015
An Anopheles stephensi mosquito obtains a blood meal from a human host through its pointed proboscis.
Scientists aiming to take the bite out of malaria have produced a strain of mosquitoes carrying genes that block its transmission, with the idea that they could breed with other members of their species in the wild and produce offspring that cannot spread the disease.
The researchers said on Monday they used gene-editing, a genetic engineering technique in which DNA can be inserted, replaced or deleted from a genome, on a species called Anopheles stephensi that spreads malaria in urban India.
They inserted DNA into the germ line, cells that pass on genes from generation to generation, of the species, creating mosquitoes with genes that prevent malaria transmission by producing malaria-blocking antibodies that are passed on to 99.5 percent of offspring.
Malaria is caused by parasites transmitted to people through the bites of infected female mosquitoes. The goal is to release genetically modified mosquitoes to mate with wild mosquitoes so that their malaria-blocking genes enter the gene pool and eventually overrun the population, short-circuiting the species' ability to infect people with the parasites.
"It can spread through a population with great efficiency, increasing from 1 percent to more than 99 percent in 10 generations, or about one season for mosquitoes," University of California-San Diego biologist Valentino Gantz said.
University of California-San Diego biologist Ethan Bier called this a "potent tool in sustainable control of malaria," as all the mosquitoes in a given region would carry anti-malarial genes.
"We do not propose that this strategy alone will eradicate malaria," University of California-Irvine molecular biologist Anthony James said.
But in conjunction with treatment and preventive drugs, future vaccines, mosquito-blocking bed nets and eradication of mosquito-breeding sites, it could play a major role in sustaining the elimination of malaria, James said.
Other scientists also have been working to create genetically engineered mosquitoes. One group last year said it created a strain carrying a gene leading nearly all offspring to be male, which could cause wild populations to plummet.
"In contrast, our much more flexible system only prevents mosquitoes from carrying malaria but can be used to do no harm to the mosquito. So it should generate the least amount of ecological damage," Bier said.
The U.N. World Health Organization estimates there will be 214 million cases of malaria worldwide in 2015 and 438,000 deaths, most in sub-Saharan Africa.
The research was published in the Proceedings of the National Academy of Sciences.
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